• Animal Genome Institute

    The Animal Genome Institute (AGI) is committed to improving the care of animals and their companion humans through genomics research. AGI also strives to train a new generation of scientists interested in genomics.

    AGI is designated as a 501(c)3 non-profit organization by the IRS. AGI is a volunteer-run organization.

     

    We care about animals and their companion humans! ❤

    We find life’s mystery in genomes ❤

    We educate next-generation scientists ❤

  • Projects

     

    Cat IBD

    Current methods for diagnosing IBD (inflammatory bowel disease) in cats are often lengthy and invasive. Early detection of gut inflammation is essential for preventing and managing the disease. BanBan, my beloved companion, suffered from IBD for nearly six years before crossing the rainbow bridge in 2012. In her memory, AGI is committed to fighting IBD in cats.

     

    We are developing a better way to detect gut inflammation early. RNA, a genetic molecule found in bodily fluids like stool, reflects the health status of organs. We recently published our first paper on the "Poopex" RNA biomarker in a mouse IBD model in exRNA and are now expanding the study to cats with IBD.

     

    Check out our study: PoopexRNA biomarker in IBD Cats.

     

    We are still seeking more participants for the cat study. If your cat has been diagnosed with IBD (or gut lymphoma), please consider donating a stool sample for our research! It's as simple as you fill out the consent form (we will provide once we confirm your eligibility), and we will send you a mailing envelope for you to return the sample to us. Upon completion of the sample submission and providing relevant health information and consent form, we will send you a $25 gift card of your choice—either Amazon or Chewy—as a token of our appreciation.

     

    Please reach out to info@animalgenomeinstitute.org if you would like to participate!

    Dog Osteosarcoma

    A close human friend of ours tragically lost her son to pediatric osteosarcoma, a rare and often fatal cancer. Due to the limited number of cases in humans, research into the diagnosis and treatment of pediatric osteosarcoma remains challenging. However, previous studies have shown that osteosarcomas in dogs are genetically similar to those in children and occur much more frequently. Advancing research in the diagnosis and treatment of canine osteosarcomas will benefit both our canine companions and children affected by this devastating disease.

     

    We have conducted a comparative transcriptome analysis of dog and human osteosarcomas. The results are currently being prepared for scientific publication, so please stay tuned!

  • All profits will be donated to the research operation of AGI

  • We are dedicated to improving the lives of animals through cutting-edge genomic research.


    Our current focus is on uncovering the genetic and molecular mechanisms behind inflammatory bowel disease (IBD) and osteosarcoma, two devastating conditions that affect countless companion animals every year.

    IBD causes chronic pain, malnutrition, and suffering in cats and dogs, often leading to lifelong treatment. Osteosarcoma, an aggressive bone cancer, frequently affects large-breed dogs and has limited treatment options. By studying the genomes and molecular pathways involved in these diseases, our goal is to develop better diagnostics, preventive strategies, and novel therapeutic approaches to give animals longer, healthier lives.

    Your donation, no matter the size, helps us:

    • Sequence and analyze animal genomes affected by IBD and osteosarcoma
    • Identify biomarkers for early detection and personalized care
    • Support collaborative research and outreach to improve animal welfare

    Every contribution brings us closer to understanding and curing these diseases.

    Thank you for supporting our mission to advance animal health through genomics.


    🐾 Together, we can make a difference.

    👉 [Donate via Zeffy – 100% of your contribution goes directly to research. No fees.]

  • Volunteer Members

    Scientists and Veterinary Clinitians

    Yuka Imamura, PhD

    Founder

    Yuka has more than 20 years of experience in genomics and bioinformatics across both academic and private research institutions. Raised on a farm in rural Japan, Yuka has long been passionate about improving animal lives and agricultural productivity through her expertise in genomics and bioinformatics. In 2019, she founded the Animal Genome Institute (AGI) to further this mission. Yuka is dedicated to supporting and educating next generation of animal/science lovers, contributing to the well-being of both animals and their human companions. She enjoys volunteering at AGI as well as at local shelters, farms, and cat cafes.

    Milena Bogunovic, MD, PhD

    Advisor

    Milena is a leading investigator of immunology, now appointed as an Associate Professor at University of Massachusetts Medical School, with a great interest in understanding how coordinated efforts of enteric immune and nervous systems maintain intestinal homeostasis and infection control, and how the dysbiosis in each system may lead to the development of inflammatory gut conditions such as Inflammatory Bowel Diseases (IBD) and Irritable Bowel Syndrome (IBS). She has been a collaborator and a friend of Yuka since she worked as an Assistant Professor at Penn State University College of Medicine and their collaborative paper was recently published in Science Immunology (PMID: 32276965).

    Tomoko Takahashi, PhD, DVM

    Advisor

    Tomoko is an Assistant Professor at School of Veterinary Science Department of Veterinary Science at Osaka Metroplitan University, Japan. Her interest is in radiation therapy for the cancer of cats and dogs. She is also a member of the Veterinary Cancer Society. Not only Tomoko is specialized in cancer therapy in cats and dogs, she sees a broad spectrum of complications in veterinary medicine, including IBD.

    Kazuki Heishima, DVM, PhD, RPS, DJCVP

    Advisor

    Kazuki is a researcher of comparative oncology and translational research, appointed as an Assistant Professor at Gifu University, Japan. His research interest is focused on developing novel therapeutic agents and low-invasive biomarkers using miRNAs for human/canine osteosarcoma (PMID: 30683101) and hemangiosarcoma (PMID: 28536479, PMID: 26335793). Kazuki is a collaborator of Yuka, and fully supports her activities.

  • My Blog

    主に備忘録用です

  • Social Feed

    Check out my latest updates!

  • EXPERIENCE

    私の過去の研究遍歴

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    Eurofins Transplant Genomics Inc

     

    Bioinformatics Scientist

    2022 -

     

    民間企業で働きたいと常々思っていたのですが、コロナその他で機が熟し、50前にして転職しました!

     

    フルリモートの解析屋です。研究したことが商品になり患者さんを救う、という点にやりがいを感じてます。

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    Penn State University College of Medicine

    Director, Penn State Hershey Genome Sciences and Bioinformatics Facility

    Associate Professor of Pharmacology, Biochemistry and Molecular Biology

    2013 - 2022

     

    憧れのコアのディレクター職に!

    NGSサンプルプレップから解析まで全部やってました。

     

    苦手なのは請求書の計算と政治。。。(汗)

    Yale University

    Associate Research Scientist

    2009 - 2013

     

    PostDoc

    2005-2008

     

    Program manager for BrainSpan Consortium Project (http://www.brainspan.org/). Studying transcriptional mechanisms involved in human brain development and evolution.

     

    ヒト脳のマイクロアレイ、NGSやってました。ボスは最近ブタ脳を蘇生させて話題になった人。。。

    The Rothberg Institute for Childhood Diseases

    Research Associate

    2008-2009

     

    NGS analysis on childhood disease

     

    NGSの基礎、R&Dラブのメンタリティはここで鍛えて頂きました。

    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas - JST ERATO Yanagisawa Orphan Receptor Project

    Postdoctoral Associate

    2001 - 2005

     

    Screening and characterization of natural ligands for orphan G protein-coupled receptors

     

    ダラス&お台場の柳沢正史研でオーファンGPCRのリガンドハンティングしてました。

  • SKILLS

    NGSに関するものなら何でも

    Molecular Biology

    NGSに関わるR&Dなら何でも

    一細胞、FFPEなど、難しいサンプルも承ってます。

    Sequencing

    イルミナを主に使ってます。時々ONT (Oxford Nanopore Technologies)、Ion Torrent、PacBio、新しくBioNanoも導入してます(sequencingというよりはmappingですが)。

    Genomics

    ヒト疾患サンプルが主な対象ですが、基礎研究ものも扱ってます。最近は植物やバクテリアのお客さんも。

    Bioinformatics

    DNA, RNA, epigenome (ChIP-seq, open chromatin, methylation), metagenome, network analysisなどもやってます。下流の解析はR, pythonを使ってます。

    Education

    小2018年からペンステートワールドキャンパス(通信教育)でバイオインフォマティクス1を教えました。医学部では単発講義がメインでしたが、学生以外も対象にNGS解析講習を開きました。

    Entrepreneurship

    念願の猫ウンチプロジェクト、遂に始動!獣医さん兼修士課程の学生さんの学位プロジェクトとしてネズミモデルで始めてます。

     

    Nonprofitの研究所を立ち上げました。動物ゲノム、バイオインフォの普及が主な活動内容です。

  • EDUCATION

    東大に10年いました

     

     

    The University of Tokyo

    Ph.D. Biochemistry and Molecular Biology 1997 – 2001

     

    医学部|清水孝雄研で生理活性脂質;GPCRの研究してました。

     

     

    The University of Tokyo

    B.S., M.Sc. Applied Biochemistry 1991 – 1997

     

    農学部|ノーバケ野口忠研で糖尿病;IGFの研究してました。

  • CONTACT US

    We are currently accepting research analysis requests! We can also provide advice to those who want to study NGS. Please feel free to contact us!

    Animal Genome Institute
    20 N. Palmyra Rd., #505
    Campbelltown PA 17010
    717-454-4211
  • CHECK OUR SNS SITES

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